Stefano George B, Fricchione Gregory L, Esch Tobias
Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA.
Med Sci Monit. 2006 Sep;12(9):HY21-31.
There appears to be a molecular process for relaxation. Given this, we attempt to demonstrate this phenomenon based on established molecular and physiological processes in light of our current understanding of central and peripheral nervous system mechanisms. Central to our hypothesis is the significance of norepinephrine, nitric oxide, dopamine and morphine signaling both in the central and peripheral nervous system. We find that nitric oxide and morphine control catecholamine processes on many levels, including synthesis, release and actions. We conclude that enough scientific information exists to support these phenotmena as actual physical processes that can be harnessed to provide better patient care.
似乎存在一种用于放松的分子过程。鉴于此,我们试图根据目前对中枢和外周神经系统机制的理解,基于已确立的分子和生理过程来证明这一现象。我们假设的核心是去甲肾上腺素、一氧化氮、多巴胺和吗啡信号在中枢和外周神经系统中的重要性。我们发现一氧化氮和吗啡在许多层面上控制儿茶酚胺过程,包括合成、释放和作用。我们得出结论,现有足够的科学信息来支持这些现象是可被利用以提供更好患者护理的实际物理过程。