与升主动脉、主动脉瓣和二尖瓣相比，冠状动脉中钙、磷和镁的早期蓄积。

Tohno Yoshiyuki, Tohno Setsuko, Mahakkanukrauh Pasuk, Azuma Cho, Moriwake Yumi, Ongkana Nutcharin, Kumai Tsukasa, Minami Takeshi, Maruyama Hirohisa

Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara 634-8521, Japan.

Biol Trace Elem Res. 2006 Jul;112(1):31-42. doi: 10.1385/BTER:112:1:31.

To explore reasons for a high accumulation of Ca and P occurring in the coronary artery of Thai with aging, the authors investigated age-related changes of elements in the coronary artery, ascending aorta near the heart, and cardiac valves in single individuals, and the relationships in the elements between the coronary artery and either the ascending aorta or cardiac valves. After an ordinary dissection by medical students at Chiang Mai University was finished, the anterior descending arteries of the left coronary artery, ascending aortas, mitral valves, and aortic valves were resected from the subjects. The subjects consisted of 17 men and 9 women, ranging in age from 46 to 76 yr. The element content was analyzed by inductively coupled plasma-atomic emission spectrometry. The average content of Ca and P was the highest in the coronary artery and decreased in the order aortic valve, ascending aorta, and mitral valve. The Ca, P, and Mg content increased in the coronary artery in the fifties and in the ascending aorta, aortic valve, and mitral valve in the sixties. It should be noted that the accumulation of Ca, P, and Mg occurred earlier in the coronary artery than in the ascending aorta, aortic valve, and mitral valve. It was found that with respect to the Ca, P, Mg, and Na contents, the coronary artery correlated well with both the aortic valve and ascending aorta, especially with the aortic valve, but it did not correlate with the mitral valves. This finding suggests that the accumulation of Ca, P, Mg, and Na occurs in the coronary artery together with the aortic valve and ascending aorta, but not together with the mitral valve. Because regarding the accumulation of Ca, P, and Mg, the ascending aorta and aortic valve are preceded by the coronary artery, it is unlikely that the accumulation of Ca, P, and Mg spreads from the ascending aorta or aortic valve to the coronary artery.

为探究泰国人冠状动脉中钙和磷随着年龄增长而大量蓄积的原因，作者研究了单一个体冠状动脉、心脏附近升主动脉及心脏瓣膜中元素随年龄的变化，以及冠状动脉与升主动脉或心脏瓣膜之间元素的关系。在清迈大学医学生完成常规解剖后，从受试者身上切除左冠状动脉前降支、升主动脉、二尖瓣和主动脉瓣。受试者包括17名男性和9名女性，年龄在46岁至76岁之间。采用电感耦合等离子体原子发射光谱法分析元素含量。冠状动脉中钙和磷的平均含量最高，其次按降序排列为主动脉瓣、升主动脉和二尖瓣。冠状动脉中钙、磷和镁的含量在五十多岁时增加，升主动脉、主动脉瓣和二尖瓣中钙、磷和镁的含量在六十多岁时增加。需要注意的是，冠状动脉中钙、磷和镁的蓄积比升主动脉、主动脉瓣和二尖瓣更早发生。研究发现，就钙、磷、镁和钠的含量而言，冠状动脉与主动脉瓣和升主动脉均有良好的相关性，尤其是与主动脉瓣，但与二尖瓣无相关性。这一发现表明，钙、磷、镁和钠的蓄积在冠状动脉中与主动脉瓣和升主动脉同时发生，但与二尖瓣不同时发生。由于就钙、磷和镁的蓄积而言，冠状动脉先于升主动脉和主动脉瓣发生，因此钙、磷和镁的蓄积从升主动脉或主动脉瓣扩散至冠状动脉的可能性不大。