Tohno Yoshiyuki, Tohno Setsuko, Satoh Hiroyasu, Minami Takeshi, Moriwake Yumi, Azuma Cho, Ohnishi Yoshiaki
Department of Anatomy, Nara Medical University, Kashihara, Japan.
Biol Trace Elem Res. 2002 Sep;88(3):203-13. doi: 10.1385/BTER:88:3:203.
To elucidate compositional changes of the mitral valve with aging, the authors investigated the relationships among element contents in the mitral valves. The subjects consisted of 10 men and 15 women, ranging in age from 65 to 102 yr. After the ordinary dissection, mitral valves, lower parts of the interventricular septa, and terminal crests containing the sinoatrial nodes were resected and the element contents were determined by inductively coupled plasma-atomic emission spectrometry. The interventricular septa and sinoatrial nodes were used to compare with the mitral valves. With regard to the mitral valve, it was found that extremely significant correlations were found among the contents of Ca, P, Mg, and Na, but no significant correlations were found between the contents of S and elements such as Ca, P, or Mg. Regarding the interventricular septum, it was found that an extremely significant correlation was found between P and S contents; very significant correlations were found between Ca and Mg contents and between Mg and S contents; and a significant correlation was found between P and Mg contents. However, no significant correlation was found between Ca and P contents in the interventricular septa. In the terminal crest containing the sinoatrial node, significant correlations were found among the contents of Ca, P, Mg, and S. The present study revealed that with regard to the relationships among element contents, the compositional change of the mitral valve was intermediate between those of the thoracic aorta and the interventricular septum.
为了阐明二尖瓣随年龄增长的成分变化，作者研究了二尖瓣中元素含量之间的关系。研究对象包括10名男性和15名女性，年龄在65岁至102岁之间。在常规解剖后，切除二尖瓣、室间隔下部以及包含窦房结的终嵴，并通过电感耦合等离子体原子发射光谱法测定元素含量。使用室间隔和窦房结与二尖瓣进行比较。关于二尖瓣，发现钙、磷、镁和钠的含量之间存在极其显著的相关性，但硫的含量与钙、磷或镁等元素之间未发现显著相关性。关于室间隔，发现磷和硫的含量之间存在极其显著的相关性；钙和镁的含量之间以及镁和硫的含量之间存在非常显著的相关性；磷和镁的含量之间存在显著相关性。然而，室间隔中钙和磷的含量之间未发现显著相关性。在包含窦房结的终嵴中，钙、磷、镁和硫的含量之间存在显著相关性。本研究表明，就元素含量之间的关系而言，二尖瓣的成分变化介于胸主动脉和室间隔之间。
