Raj Satish R
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Departments of Medicine & Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-2195, USA.
Indian Pacing Electrophysiol J. 2006 Apr 1;6(2):84-99.
Postural tachycardia syndrome (POTS), characterized by orthostatic tachycardia in the absence of orthostatic hypotension, has been the focus of increasing clinical interest over the last 15 years 1. Patients with POTS complain of symptoms of tachycardia, exercise intolerance, lightheadedness, extreme fatigue, headache and mental clouding. Patients with POTS demonstrate a heart rate increase of >or=30 bpm with prolonged standing (5-30 minutes), often have high levels of upright plasma norepinephrine (reflecting sympathetic nervous system activation), and many patients have a low blood volume. POTS can be associated with a high degree of functional disability. Therapies aimed at correcting the hypovolemia and the autonomic imbalance may help relieve the severity of the symptoms. This review outlines the present understanding of the pathophysiology, diagnosis, and management of POTS.
体位性心动过速综合征（POTS）的特征是在无体位性低血压的情况下出现体位性心动过速，在过去15年中一直是临床日益关注的焦点1。POTS患者诉说有心悸、运动不耐受、头晕、极度疲劳、头痛和思维模糊等症状。POTS患者在长时间站立（5 - 30分钟）时心率增加≥30次/分钟，常常有高水平的直立位血浆去甲肾上腺素（反映交感神经系统激活），并且许多患者血容量低。POTS可伴有高度的功能残疾。旨在纠正血容量不足和自主神经失衡的治疗可能有助于减轻症状的严重程度。本综述概述了目前对POTS病理生理学、诊断和管理的认识。
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