Casterline C L, Evans R
J Allergy Clin Immunol. 1977 Jun;59(6):420-4. doi: 10.1016/0091-6749(77)90004-5.
This study was designed to better define the mechanism of histamine-induced bronchoconstriction in humans by pharmacologic manipulation of the postulated bronchial histamine receptor sites. Histamine challenges were performed on a heterogeneous group of adult asthmatic subjects. The cumulative units of histamine required for induction of a sustained 20% or greater decrease in FEV1 from baseline were determined. The effect of pretreatment with an aerosolized H1 receptor antagonist, diphenhydramine hydrochloride, was then studied. Analysis of the data showed that the administration of an H1 receptor antagonist prior to histamine challenge significantly blocked the bronchial response to histamine (p less than 0.005). This effect was considered to be due to specific competitive antagonism at the H1 receptor site and suggests the presence of H1 receptors in human bronchial mucosa.
本研究旨在通过对假定的支气管组胺受体部位进行药理操作，更好地确定组胺诱导人类支气管收缩的机制。对一组异质性成年哮喘患者进行了组胺激发试验。测定了从基线开始使第一秒用力呼气容积（FEV1）持续下降20%或更多所需的组胺累积单位。然后研究了雾化H1受体拮抗剂盐酸苯海拉明预处理的效果。数据分析表明，在组胺激发试验前给予H1受体拮抗剂可显著阻断支气管对组胺的反应（p<0.005）。这种效应被认为是由于在H1受体部位的特异性竞争性拮抗作用，提示人支气管黏膜中存在H1受体。
