吸入性H1和H2受体拮抗剂对正常人和哮喘患者的作用。
Effect of inhaled H1 and H2 receptor antagonist in normal and asthmatic subjects.
作者信息
Thomson N C, Kerr J W
出版信息
Thorax. 1980 Jun;35(6):428-34. doi: 10.1136/thx.35.6.428.
The effects on airflow resistance of an inhaled H1 receptor antagonist, clemastine, and an H2 receptor antagonist, cimetidine, have been investigated in normal and asthmatic subjects. No significant changes in specific conductance (sGaw) were seen in six normal subjects. In eight asthmatic subjects a significant increase in forced expiratory volume in one second (FEV1) occurred at 60 min (< 0.02), and 120 (< 0.05) after the inhalation of clemastine, whereas inhaled cimetidine had no effect on airflow resistance. Clemastine and cimetidine were tested on histamine-induced bronchoconstriction in eight normal and eight asthmatic subjects. Clemastine significantly reduced the fall in sGaw in normal subjects and the fall in FEV1 in asthmatic subjects, whereas cimetidine had no protective effect. Clemastine and ipratropium bromide were tested on methacholine-induced bronchoconstriction in eight normal subjects. Ipratropium bromide, but not clemastine, significantly reduced the fall in sGaw after methacholine. These results suggest that in normal and asthmatic subjects histamine-induced bronchoconstriction is mediated predominantly via H1 rather than H2 receptors in the airways.
在正常人和哮喘患者中，研究了吸入性H1受体拮抗剂氯马斯汀和H2受体拮抗剂西咪替丁对气流阻力的影响。6名正常受试者的比气道传导率（sGaw）未见明显变化。8名哮喘患者在吸入氯马斯汀后60分钟（<0.02）和120分钟（<0.05）时，一秒用力呼气容积（FEV1）显著增加，而吸入西咪替丁对气流阻力无影响。在8名正常人和8名哮喘患者中测试了氯马斯汀和西咪替丁对组胺诱导的支气管收缩的作用。氯马斯汀可显著降低正常受试者的sGaw下降以及哮喘患者的FEV1下降，而西咪替丁无保护作用。在8名正常受试者中测试了氯马斯汀和异丙托溴铵对乙酰甲胆碱诱导的支气管收缩的作用。异丙托溴铵可显著降低乙酰甲胆碱后sGaw的下降，而氯马斯汀无此作用。这些结果表明，在正常人和哮喘患者中，组胺诱导的支气管收缩主要通过气道中的H1而非H2受体介导。
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