Brinkman Maree, Buntinx Frank, Muls Erik, Zeegers Maurice P
Department of General Practice, Katholieke University of Leuven, Leuven, Belgium.
Lancet Oncol. 2006 Sep;7(9):766-74. doi: 10.1016/S1470-2045(06)70862-2.
The anticarcinogenic potential of selenium was first identified nearly 40 years ago in geographical studies that reported lower death rates for cancer in regions with high levels of selenium. Cancer of the bladder was one of the body sites found to share this inverse association. Although many subsequent studies have been done on selenium and cancer, only a few have specifically assessed the relation with bladder cancer. However, the high recurrence rate and ability to monitor bladder urothelial-cell carcinoma make selenium a good candidate for chemoprevention. Evidence suggests that selenium is a biologically plausible, safe, and efficacious potential chemoprevention agent for bladder cancer. Large tertiary chemoprevention trials are needed to further investigate the role of selenium in the prevention of bladder cancer. Future studies should assess the best dose and form of selenium, and whether the protective effect of selenium differs between the sexes.
近40年前，在地理研究中首次发现了硒的抗癌潜力，这些研究报告称，在硒含量高的地区，癌症死亡率较低。膀胱癌是发现存在这种负相关关系的身体部位之一。尽管随后对硒与癌症进行了许多研究，但只有少数研究专门评估了与膀胱癌的关系。然而，膀胱癌的高复发率以及对膀胱尿路上皮细胞癌的监测能力，使得硒成为化学预防的理想候选物质。有证据表明，硒是一种在生物学上看似合理、安全且有效的膀胱癌化学预防潜在药物。需要进行大型三级化学预防试验，以进一步研究硒在预防膀胱癌中的作用。未来的研究应评估硒的最佳剂量和形式，以及硒的保护作用在性别之间是否存在差异。
