Department of Psychiatry, University of Pennsylvania, 415 Curie Blvd., Philadelphia, PA 19104, USA.
World Psychiatry. 2003 Jun;2(2):68-72.
Bipolar disorder (BPD) and schizophrenia (SZ) may have some susceptibility genes in common, despite the fact that current nosology separates them into non-overlapping categories. The evidence for shared genetic factors includes epidemiologic characteristics, family studies and overlap in confirmed linkages. Review of these data indicates that there are five genomic regions which may represent shared genetic susceptibility of BPD and SZ. As the genes underlying these confirmed linkages are identified, the current nosology must be changed to reflect the new knowledge concerning the shared etiologies of BPD and SZ.
双相情感障碍 (BPD) 和精神分裂症 (SZ) 可能有一些共同的易感基因,尽管目前的分类学将它们分为不重叠的类别。共同遗传因素的证据包括流行病学特征、家族研究和已确认的连锁重叠。对这些数据的回顾表明,有五个基因组区域可能代表 BPD 和 SZ 的共同遗传易感性。随着这些已确认的连锁基因的确定,目前的分类学必须改变,以反映有关 BPD 和 SZ 共同病因的新知识。