Olin Neuropsychiatry Research Center, Hartford Hospital/Institute of Living, Hartford, CT 06106, USA.
Biol Psychiatry. 2013 Sep 15;74(6):458-66. doi: 10.1016/j.biopsych.2013.04.024. Epub 2013 Jun 5.
Schizophrenia and bipolar disorder share overlapping symptoms and risk genes. Shared aberrant functional connectivity is hypothesized in both disorders and in relatives.
We investigated resting state functional magnetic resonance imaging in 70 schizophrenia and 64 psychotic bipolar probands, their respective first-degree relatives (n = 70 and 52), and 118 healthy subjects. We used independent component analysis to identify components representing various resting state networks and assessed spatial aspects of functional connectivity within all networks. We first investigated group differences using five-level, one-way analysis of covariance (ANCOVA), followed by post hoc t tests within regions displaying ANCOVA group differences and correlation of such functional connectivity measures with symptom ratings to examine clinical relationships.
Seven networks revealed abnormalities (five-level one-way ANCOVA, family-wise error correction p < .05): A) fronto-occipital, B) midbrain/cerebellum, C) frontal/thalamic/basal ganglia, D) meso/paralimbic, E) posterior default mode network, F) fronto-temporal/paralimbic and G) sensorimotor networks. Abnormalities in networks B and F were unique to schizophrenia probands. Furthermore, abnormalities in networks D and E were common to both patient groups. Finally, networks A, C, and G showed abnormalities shared by probands and their relative groups. Negative correlation with Positive and Negative Syndrome Scale negative and positive scores were found in regions within network C and F respectively, and positive correlation with Positive and Negative Syndrome Scale negative scores was found in regions in network D among schizophrenia probands only.
Schizophrenia, psychotic bipolar probands, and their relatives share both unique and overlapping within-network brain connectivity abnormalities, revealing potential psychosis endophenotypes.
精神分裂症和双相情感障碍具有重叠的症状和风险基因。在这两种疾病以及在亲属中，都假设存在共享的异常功能连接。
我们对 70 名精神分裂症和 64 名精神病性双相障碍先证者、他们各自的一级亲属（n = 70 和 52）以及 118 名健康对照者进行了静息状态功能磁共振成像研究。我们使用独立成分分析来识别代表各种静息状态网络的成分，并评估所有网络中功能连接的空间方面。我们首先使用五水平单向方差分析（ANCOVA）来研究组间差异，然后在显示 ANCOVA 组间差异的区域内进行事后 t 检验，并对这些功能连接测量与症状评分的相关性进行了分析，以检查临床关系。
七个网络显示出异常（五水平单向 ANCOVA，家族错误校正 p <.05）：A）额枕部、B）中脑/小脑、C）额/丘脑/基底节、D）中/边缘、E）后默认模式网络、F）额颞/边缘和 G）感觉运动网络。网络 B 和 F 的异常仅见于精神分裂症先证者。此外，网络 D 和 E 的异常在两个患者组中都很常见。最后，网络 A、C 和 G 显示出先证者及其亲属群体共有的异常。在网络 C 和 F 的区域中，发现与阳性和阴性综合征量表阴性和阳性评分呈负相关，而仅在精神分裂症先证者中，在网络 D 的区域中发现与阳性和阴性综合征量表阴性评分呈正相关。
精神分裂症、精神病性双相障碍先证者及其亲属共享独特和重叠的网络内大脑连接异常，揭示了潜在的精神病表型。
