Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
Bipolar Disord. 2009 Nov;11(7):753-8. doi: 10.1111/j.1399-5618.2009.00745.x.
The cerebellar vermis is increasingly implicated in bipolar disorder (BD). In this study, we investigated vermis morphology in BD using a quantitative volumetric analysis.
Volumes for total vermis and vermis subregions V1 (lobules I-V), V2 (lobules VI-VII), and V3 (lobules VIII-X) were calculated using high-resolution structural magnetic resonance imaging obtained from 44 individuals with BD (25 females and 19 males) and 43 healthy comparison (HC) subjects (26 females and 17 males). Total vermis volumes were compared between the BD and HC groups. Potential effects of vermis subregions and clinical features were explored.
Total vermis volumes were significantly larger in the BD group than in the HC group (p = 0.02). There was a significant group-by-sex interaction (p = 0.02). Total vermis volumes were significantly larger in males with BD than HC males (p = 0.004); vermis volumes did not differ significantly between females with and without BD (p = 0.95). Subregion analyses showed a trend-level interaction between diagnosis and subregion (p = 0.07) in which subregion V1 volumes were significantly larger in BD participants (p = 0.001), with differences primarily driven by males (p = 0.001).
Our findings demonstrate increases in cerebellar vermis volumes in males with BD. These findings support the presence of structural alterations in the cerebellar vermis in BD and furthermore the influence of sex on such changes.
小脑蚓部越来越多地与双相障碍（BD）有关。在这项研究中，我们使用定量容积分析研究了 BD 中小脑蚓部的形态。
使用来自 44 名 BD 患者（25 名女性和 19 名男性）和 43 名健康对照组（HC）受试者（26 名女性和 17 名男性）的高分辨率结构磁共振成像，计算小脑蚓部的总容积和蚓部各亚区（V1[I-V 叶]、V2[VI-VII 叶]和 V3[VIII-X 叶]）的体积。比较 BD 和 HC 组之间的小脑蚓部总容积。探讨了蚓部各亚区和临床特征的潜在影响。
BD 组的小脑蚓部总容积明显大于 HC 组（p = 0.02）。存在蚓部亚区和诊断之间的显著组间性别交互作用（p = 0.02）。BD 男性的小脑蚓部总容积明显大于 HC 男性（p = 0.004）；BD 女性与无 BD 女性之间的小脑蚓部容积无显著差异（p = 0.95）。亚区分析显示诊断与亚区之间存在趋势水平的交互作用（p = 0.07），其中 BD 患者的 V1 亚区体积明显增大（p = 0.001），差异主要由男性驱动（p = 0.001）。
我们的研究结果表明，BD 男性的小脑蚓部体积增加。这些发现支持 BD 中小脑蚓部存在结构改变，并且进一步表明性别对这些变化的影响。
