Kocak A Kadir, Bor Ozcan, Yildiz Bilal, Erdogan Levent, Us Tercan
Department of Pediatrics, School of Medicine, Osmangazi University, Eskisehir, Turkey.
Allergy Asthma Proc. 2006 Jul-Aug;27(4):371-7. doi: 10.2500/aap.2006.27.2885.
The aim of this study was to evaluate the immunologic parameters and the effects of glucocorticoid treatment, the absolute numbers of CD4+/CD25+ T lymphocytes, eosinophil counts, levels of eosinophilic cationic protein (ECP), and interleukin (IL)-5 in peripheral blood of patients having acute asthma exacerbations and healthy children were investigated. Samples for the absolute numbers CD4+/CD25+ T lymphocyte and eosinophil count, ECP, and IL-5 were obtained before (day 1) and after (day 5) glucocorticoid treatment. Forced expiratory volume in 1 second and peak expiratory flow rate were measured on days 1 and 5 in asthma patients (n = 25) and in the control group (n = 15). The absolute numbers of CD4+/CD25+ T lymphocyte and eosinophils, levels of ECP, and IL-5 were significantly greater, while forced expiratory volume in 1 second and peak expiratory flow rate were significantly less in the patients with asthma than in the control subjects on day 1. These parameters normalized after glucocorticoid treatment with clinical improvement by day 5. Glucocorticoid treatment is associated with clinical and laboratory improvement achieved in patients with acute asthma exacerbations.
本研究的目的是评估免疫参数以及糖皮质激素治疗的效果，对急性哮喘加重期患者和健康儿童外周血中CD4+/CD25+ T淋巴细胞的绝对计数、嗜酸性粒细胞计数、嗜酸性粒细胞阳离子蛋白（ECP）水平以及白细胞介素（IL）-5进行了研究。在糖皮质激素治疗前（第1天）和治疗后（第5天）获取CD4+/CD25+ T淋巴细胞绝对计数、嗜酸性粒细胞计数、ECP和IL-5的样本。在第1天和第5天对哮喘患者（n = 25）和对照组（n = 15）测量第1秒用力呼气量和呼气峰值流速。在第1天，哮喘患者的CD4+/CD25+ T淋巴细胞和嗜酸性粒细胞的绝对计数、ECP水平和IL-5显著更高，而第1秒用力呼气量和呼气峰值流速显著低于对照组。到第5天，随着临床症状改善，糖皮质激素治疗后这些参数恢复正常。糖皮质激素治疗与急性哮喘加重期患者临床和实验室指标的改善相关。
