Neonakis Ioannis, Mantadakis Elpis, Gitti Zoe, Mitrouska Ioanna, Manidakis Louis George, Maraki Sofia, Samonis George
Laboratory of Mycobacteriology, Department of Clinical Bacteriology, Parasitology, Zoonoses, and Geographical Medicine, University Hospital of Heraklion, 712 01 Heraklion, Crete, Greece.
Ann Clin Microbiol Antimicrob. 2006 Sep 1;5:20. doi: 10.1186/1476-0711-5-20.
Female genital tuberculosis is an uncommon disease that is rarely diagnosed in developed countries.
A 61-year-old postmenopausal woman who had undergone surgery and treated with adjuvant chemotherapy for infiltrating ductal carcinoma of the breast five years ago, presented with bloody vaginal discharge, fatigue, weight loss, and low grade fevers at night for two months. Histological examination of the endometrium, done based on the suspicion of a second primary cancer due to the tamoxifen therapy, revealed a granulomatous reaction. Liquid and solid mycobacterial cultures of the tissues were performed. Although the acid fast staining was negative, the liquid culture was positive for Mycobacterium tuberculosis. Involvement of other systems was not detected. The patient was treated with a three-drug antituberculosis regimen for 9 months and recovered fully.
Female genital tuberculosis is a rare but curable disease that should be included in the differential diagnosis of women with menstrual problems. Early diagnosis is important and may prevent unnecessary invasive procedures for the patient.
女性生殖器结核是一种罕见疾病，在发达国家很少被诊断出来。
一名61岁的绝经后女性，五年前因浸润性乳腺导管癌接受了手术及辅助化疗，两个月来出现血性白带、疲劳、体重减轻和夜间低热。因怀疑他莫昔芬治疗导致第二原发性癌症而对子宫内膜进行组织学检查，结果显示为肉芽肿反应。对组织进行了液体和固体分枝杆菌培养。虽然抗酸染色为阴性，但液体培养结果显示结核分枝杆菌呈阳性。未检测到其他系统受累。患者接受了为期9个月的三联抗结核治疗，完全康复。
女性生殖器结核是一种罕见但可治愈的疾病，应列入有月经问题女性的鉴别诊断中。早期诊断很重要，可避免患者进行不必要的侵入性检查。
