Wright Thomas C, Van Damme Pierre, Schmitt Heinz-Josef, Meheus André
Department of Pathology, Columbia University, 630 W. 168th Street, New York, NY 10032, USA.
Vaccine. 2006 Aug 31;24 Suppl 3:S3/122-31. doi: 10.1016/j.vaccine.2006.05.118.
Introduction of a vaccine requires the achievement of three initial milestones. These are licensure by a national control authority that determines the vaccine is safe and effective, development of recommendations for use by expert advisory bodies on immunization, and obtaining funding for vaccination. Once these milestones have been achieved, a successful vaccination program requires that a number of interlinked programmatic components be brought together in a coordinated fashion. These include vaccine purchase and supply, vaccination service delivery, high coverage rates, surveillance of the vaccination program, immunization finance policies and practices, and political will. Human papillomavirus (HPV) vaccination provides unique challenges in all of these areas because of the many gaps in our knowledge.
疫苗的引进需要达成三个初步里程碑。这些包括获得国家监管机构的许可，该机构确定疫苗是安全有效的；由免疫专家咨询机构制定使用建议；以及获得疫苗接种资金。一旦达成这些里程碑，成功的疫苗接种计划需要以协调的方式将一些相互关联的计划组成部分整合在一起。这些包括疫苗采购与供应、疫苗接种服务提供、高覆盖率、疫苗接种计划监测、免疫融资政策与实践以及政治意愿。由于我们在知识方面存在诸多空白，人乳头瘤病毒（HPV）疫苗接种在所有这些领域都带来了独特的挑战。
