Hnasko Thomas S, Edwards Robert H
Department of Neurology, School of Medicine, University of California-San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94158, USA.
Neuron. 2006 Sep 7;51(5):523-4. doi: 10.1016/j.neuron.2006.08.019.
The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In this issue of Neuron, Prado et al. pursue this line of investigation and show that changes in transporter expression that alter quantal size can affect behavior.
通过突触前而非突触后机制对量子大小进行调节，作为一种潜在的可塑性机制，近来受到了广泛关注。囊泡转运体催化突触囊泡被递质填充，因此是这种突触前调节的潜在作用底物。在本期《神经元》杂志中，普拉多等人沿着这一研究方向展开探索，结果表明，转运体表达的变化会改变量子大小，进而可能影响行为。
