Liu Y, Waites C, Krantz D, Tan P, Edwards R H
Department of Neurology, University of California at San Francisco, School of Medicine 94143-0435, USA.
Cold Spring Harb Symp Quant Biol. 1996;61:747-58.
Molecular cloning of the transport proteins involved in packaging monoamines and ACh into secretory vesicles has implicated their activity in neural degeneration as well as signaling. Future studies will explore further the mechanism of active transport, its regulation, and the membrane trafficking of the proteins with the long-term goal of understanding how the regulation of transmitter release and, in particular, quantal size influences information processing and behavior. In addition, the bioenergetics of vesicular GABA and glutamate transport suggests that the proteins responsible for these activities may belong to a distinct gene family.
参与将单胺和乙酰胆碱包装到分泌囊泡中的转运蛋白的分子克隆表明它们在神经变性以及信号传导中发挥作用。未来的研究将进一步探索主动转运的机制、其调节以及蛋白质的膜运输，其长期目标是了解神经递质释放的调节，特别是量子大小如何影响信息处理和行为。此外，囊泡γ-氨基丁酸和谷氨酸转运的生物能量学表明，负责这些活动的蛋白质可能属于一个独特的基因家族。
