Volk Heather E, Todd Richard D
Doctoral Program in Public Health Studies, Saint Louis University School of Public Health, Saint Louis, Missouri 63110, USA.
Biol Psychiatry. 2007 Jul 15;62(2):115-20. doi: 10.1016/j.biopsych.2006.05.036. Epub 2006 Sep 1.
A profile of Child Behavior Checklist(CBCL) T-scores>or=70 on the attention problems, aggression, and anxious/depressed subscales has been proposed to identify juvenile bipolar disorder(JBD). We tested this hypothesis in a population-based sample.
Data for this analysis come from a birth-records-based twin sample having semi-structured interview and CBCL data (N=1,346). We compared prevalence of DSM-IV psychiatric disorders and suicidal behaviors in CBCL-JBD and non-CBCL-JBD subjects. Twin modeling assessed genetic and environmental contributions to CBCL-JBD. Associations with DRD4 and DAT1 were examined using chi-square tests.
The prevalence of CBCL-JBD was 2.5%. No subjects with CBCL-JBD met criteria for bipolar or other mood disorders. CBCL-JBD subjects had more oppositional defiant disorder (ODD), conduct disorder(CD), and attention deficit hyperactivity disorder(ADHD). The CBCL-JBD profile was uncommon in these disorders. CBCL-JBD subjects more frequently endorsed suicidal behaviors. The CBCL-JBD profile was heritable and associated with the number of DAT1 9-repeat 3' untranslated region alleles.
The CBCL-JBD phenotype does not correspond with a semi-structured interview assessment of JBD. ADHD, CD, and ODD are common in children with CBCL-JBD but do not account for the profile. Increased suicidal behaviors indicate substantial impairment in CBCL-JBD subjects.
有人提出，儿童行为清单（CBCL）在注意力问题、攻击行为和焦虑/抑郁分量表上的T分数≥70可用于识别青少年双相情感障碍（JBD）。我们在一个基于人群的样本中对这一假设进行了检验。
本分析的数据来自一个基于出生记录的双胞胎样本，该样本有半结构化访谈和CBCL数据（N = 1346）。我们比较了CBCL-JBD和非CBCL-JBD受试者中DSM-IV精神障碍和自杀行为的患病率。双胞胎模型评估了遗传和环境对CBCL-JBD的影响。使用卡方检验检查与DRD4和DAT1的关联。
CBCL-JBD的患病率为2.5%。没有CBCL-JBD受试者符合双相情感障碍或其他情绪障碍的标准。CBCL-JBD受试者有更多的对立违抗障碍（ODD）、品行障碍（CD）和注意力缺陷多动障碍（ADHD）。CBCL-JBD特征在这些障碍中并不常见。CBCL-JBD受试者更频繁地认可自杀行为。CBCL-JBD特征具有遗传性，并且与DAT1 9重复3'非翻译区等位基因的数量有关。
CBCL-JBD表型与JBD的半结构化访谈评估不相符。ADHD、CD和ODD在CBCL-JBD儿童中很常见，但不能解释该特征。自杀行为增加表明CBCL-JBD受试者存在严重损害。
