Hudziak James J, Althoff Robert R, Derks Eske M, Faraone Stephen V, Boomsma Dorret I
Department of Psychiatry, University of Vermont, Burlington 05405, USA.
Biol Psychiatry. 2005 Oct 1;58(7):562-8. doi: 10.1016/j.biopsych.2005.03.024.
No consensus has been reached yet on how best to characterize children with juvenile bipolar disorder (JBD). Several groups have shown that children on the attention problems (AP), aggressive behavior (AGG), and anxious-depressed (AD) syndromes of the Child Behavior Checklist (CBCL) are likely to meet criteria for DSM-JBD. We aimed to use a large population-based twin sample to evaluate the prevalence and genetic architecture of the CBCL-JBD (deviant on AP, AGG, and AD) phenotype and compare these data to children who are deviant on just the CBCL-AP syndrome.
Structural equation modeling (SEM) was applied to CBCL data from 5418, 3562, and 1971 Dutch twin pairs at ages 7, 10, and 12 years.
The CBCL-JBD phenotype occurs in approximately 1% of children at each age. Among the children who meet criteria for the CBCL-AP phenotype ( approximately 5%), between 13 and 20% also meet criteria for CBCL-JBD. The best SEM for CBCL-JBD includes additive genetic, shared and unique environmental factors. The best SEM for CBCL-AP includes dominant and additive genetic and unique environmental factors.
These data suggest that CBCL-JBD is common, and even more common among children who have severe attention problems. CBCL-JBD shows familial aggregation due to both genetic and shared environmental factors.
对于如何最好地界定青少年双相情感障碍（JBD）儿童，目前尚未达成共识。多个研究小组表明，在儿童行为清单（CBCL）中存在注意力问题（AP）、攻击行为（AGG）和焦虑抑郁（AD）综合征的儿童可能符合DSM-JBD的标准。我们旨在使用一个基于大规模人群的双胞胎样本，评估CBCL-JBD（在AP、AGG和AD方面异常）表型的患病率和遗传结构，并将这些数据与仅在CBCL-AP综合征方面异常的儿童进行比较。
对来自5418对、3562对和1971对7岁、10岁和12岁荷兰双胞胎的CBCL数据应用结构方程模型（SEM）。
CBCL-JBD表型在各年龄段儿童中约占1%。在符合CBCL-AP表型标准的儿童中（约5%），13%至20%也符合CBCL-JBD标准。CBCL-JBD的最佳SEM包括加性遗传、共享和独特环境因素。CBCL-AP的最佳SEM包括显性和加性遗传以及独特环境因素。
这些数据表明，CBCL-JBD很常见，在有严重注意力问题的儿童中更为常见。CBCL-JBD由于遗传和共享环境因素而表现出家族聚集性。
