核仁组织区：乳腺癌新的预后变量
Nucleolar organiser regions: new prognostic variable in breast carcinomas.
作者信息
Sivridis E, Sims B
机构信息
Department of Histopathology, General Hospital, Alexandroupolis, Greece.
出版信息
J Clin Pathol. 1990 May;43(5):390-2. doi: 10.1136/jcp.43.5.390.
Abstract
Nucleolar organiser regions (NORs), which are important for regulating protein synthesis, were identified in 20 breast carcinomas by means of a silver (Ag) staining technique. Infiltrating neoplasms with metastases in four or more axillary lymph nodes possessed, on average, a greater number of AgNORs per cell nucleus compared with neoplasms without nodal disease, or with one to three positive lymph nodes. The size, morphology, and distribution of AgNORs within the nucleus were also different in the two study groups. Overall, these findings suggest that breast carcinomas with multiple, irregular, and widely dispersed AgNORs tend to be of high grade malignancy.
摘要
核仁组织区（NORs）对调节蛋白质合成很重要，通过银（Ag）染色技术在20例乳腺癌中得以识别。与无淋巴结转移或有1至3个阳性淋巴结的肿瘤相比，在四个或更多腋窝淋巴结有转移的浸润性肿瘤，其每个细胞核平均拥有更多的AgNORs。两个研究组中，细胞核内AgNORs的大小、形态和分布也有所不同。总体而言，这些发现表明，具有多个、不规则且广泛分散的AgNORs的乳腺癌往往具有高度恶性。
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