Egan M, Raafat F, Crocker J, Williams D
Birmingham Children's Hospital.
J Clin Pathol. 1988 May;41(5):527-31. doi: 10.1136/jcp.41.5.527.
Twenty confirmed cases of childhood neuroblastoma diagnosed over six years were reviewed and classified according to the subtyping proposed by Shimada et al. The tumours were stained using a silver colloid method for nucleolar organiser regions (NORs), and the mean number of NORs for every 200 cells was calculated. The correlation between the mean number of NORs and histology and survival was studied. There was a significant correlation between the mean numbers of NORs and differentiation, and with the mitosis-karyorrhexis index (MKI) in the stroma poor group (p = 0.01-0.001). A trend to increased survival with decreased numbers of NORs was observed in the study group as a whole (rank order of correlation = -0.57, p = 0.05-0.02). It is suggested that mean number of NORs is of prognostic value in neuroblastomas.
回顾了六年间确诊的20例儿童神经母细胞瘤病例，并根据岛田等人提出的亚型进行分类。采用银胶体法对肿瘤的核仁组成区（NORs）进行染色，并计算每200个细胞中NORs的平均数。研究了NORs平均数与组织学及生存率之间的相关性。在基质贫乏组中，NORs平均数与分化程度以及有丝分裂-核溶解指数（MKI）之间存在显著相关性（p = 0.01 - 0.001）。在整个研究组中观察到NORs数量减少时生存趋势增加（相关等级顺序 = -0.57，p = 0.05 - 0.02）。提示NORs平均数在神经母细胞瘤中具有预后价值。
