Basso D, Panozzo M P, Fabris C, del Favero G, Meggiato T, Fogar P, Meani A, Faggian D, Plebani M, Burlina A
Istituto di Medicina, Interna (Cattedra di Malattie Apparato Digerente) Padua, Italy.
J Clin Pathol. 1990 May;43(5):403-5. doi: 10.1136/jcp.43.5.403.
To ascertain modifications in the activation products derived from oxygen free radicals in patients with chronic pancreatic and extra-pancreatic diseases, lipid peroxide activity was measured in the sera of 40 control subjects, 28 patients with pancreatic cancer, 49 with chronic pancreatitis, and 53 with extra-pancreatic diseases. In 142 of the subjects, elastase 1, amylase, and pancreatic isoamylase activities were also determined. Increased lipid peroxide activities were found in some patients with both chronic pancreatic and extra-pancreatic diseases. Patients with chronic pancreatitis studied during relapse had higher activities of lipid peroxides than those without active disease. No difference was found between the values in patients with pancreatic cancer with liver metastases and those without. Correlations were found between lipid peroxides and both amylase and pancreatic isoamylase activities; no correlation was detected between lipid peroxides and elastase 1. In benign biliary tract disease a correlation was detected between lipid peroxides and alanine aminotransferase and alkaline phosphatase activities. In all patients, however, a correlation was found between alkaline phosphatase and lipid peroxide activities. It is concluded that activation of oxygen derived free radicals occurs in chronic pancreatic as well as in extra-pancreatic disease; it seems to reflect the degree of inflammation.
为了确定慢性胰腺疾病和胰腺外疾病患者中氧自由基衍生的活化产物的变化，对40名对照受试者、28名胰腺癌患者、49名慢性胰腺炎患者和53名胰腺外疾病患者的血清进行了脂质过氧化物活性测定。在142名受试者中，还测定了弹性蛋白酶1、淀粉酶和胰腺同工淀粉酶的活性。在一些慢性胰腺疾病和胰腺外疾病患者中发现脂质过氧化物活性增加。复发期的慢性胰腺炎患者的脂质过氧化物活性高于无活动性疾病的患者。有肝转移的胰腺癌患者和无肝转移的患者之间的值没有差异。脂质过氧化物与淀粉酶和胰腺同工淀粉酶活性之间存在相关性；脂质过氧化物与弹性蛋白酶1之间未检测到相关性。在良性胆道疾病中，脂质过氧化物与丙氨酸转氨酶和碱性磷酸酶活性之间存在相关性。然而，在所有患者中，碱性磷酸酶与脂质过氧化物活性之间存在相关性。结论是，氧衍生自由基的活化发生在慢性胰腺疾病以及胰腺外疾病中；它似乎反映了炎症程度。
