Pezzilli R, Billi P, Barakat B, Fiocchi M, Miglio F
Medicina d'Urgenza, Ospedale Sant'Orsola, Bologna, Italy.
Ital J Gastroenterol Hepatol. 1997 Apr;29(2):174-8.
The aim of this study was to evaluate the incidence in the serum of elevated levels of amylase, pancreatic isoamylase, and lipase in acute alcohol intoxication among occasional drinkers and chronic alcoholics, and to assess the diagnostic ability of the three enzymes for acute alcoholic pancreatitis.
One-hundred and seventeen consecutive subjects with acute alcohol intoxication but no abdominal pain (47 occasional drinkers, 70 chronic alcoholics), and 17 with acute alcoholic pancreatitis were studied. For all subjects serum amylase, pancreatic isoamylase, and lipase were determined using commercially available kits.
Among occasional drinkers, serum amylase levels were abnormally high in 6 subjects (13%), whereas serum pancreatic isoamylase and lipase were abnormally high in one, (2%). In chronic alcoholics without abdominal pain serum amylase and lipase were abnormally high in 10 subjects (14%) but serum pancreatic isoamylase in only 7 (10%). In patients with acute alcoholic pancreatitis, serum amylase and pancreatic isoamylase were abnormally high in 16 of the 17 patients (94%), whereas serum lipase was abnormally high in all.
Chronic alcohol abuse, but not occasional alcohol intoxication, may cause pancreatic damage. Amylase, pancreatic isoamylase and lipase determinations in the serum are all equally useful in the diagnosis of acute alcoholic pancreatitis.
本研究旨在评估偶尔饮酒者和慢性酗酒者急性酒精中毒时血清淀粉酶、胰腺同工淀粉酶和脂肪酶水平升高的发生率，并评估这三种酶对急性酒精性胰腺炎的诊断能力。
对117例连续的急性酒精中毒但无腹痛的受试者（47例偶尔饮酒者，70例慢性酗酒者）以及17例急性酒精性胰腺炎患者进行了研究。对所有受试者使用市售试剂盒测定血清淀粉酶、胰腺同工淀粉酶和脂肪酶。
在偶尔饮酒者中，6例受试者（13%）血清淀粉酶水平异常升高，而血清胰腺同工淀粉酶和脂肪酶异常升高的各有1例（2%）。在无腹痛的慢性酗酒者中，10例受试者（14%）血清淀粉酶和脂肪酶异常升高，但血清胰腺同工淀粉酶仅7例（10%）异常升高。在急性酒精性胰腺炎患者中，17例患者中有16例（94%）血清淀粉酶和胰腺同工淀粉酶异常升高，而所有患者血清脂肪酶均异常升高。
慢性酒精滥用而非偶尔酒精中毒可能导致胰腺损伤。血清淀粉酶、胰腺同工淀粉酶和脂肪酶测定在急性酒精性胰腺炎的诊断中同样有用
