一种抗HIV gp120抗体Fab片段的初步晶体学分析。
Preliminary crystallographic analysis of the Fab fragment of an antibody against HIV gp120.
作者信息
Vyas M N, Vyas N K, Liou R S, Chang T W, Quiocho F A
机构信息
Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030.
出版信息
J Mol Biol. 1990 Jul 5;214(1):23-4. doi: 10.1016/0022-2836(90)90142-9.
PMID:1695249
Abstract
Single crystals of the Fab fragment of a murine monoclonal antibody BAT123 (IgG1, kappa) raised against a dominant neutralizing determinant of gp120 of HIV that are suitable for X-ray structural analysis have been obtained. The thick prismatic plate crystals belong to space group P2(1)2(1)2 with unit cell dimensions of a = 177.42 A, b = 37.36 A and c = 73.30 A.
摘要
已获得针对HIV的gp120主要中和决定簇产生的鼠单克隆抗体BAT123（IgG1，κ）Fab片段的适合X射线结构分析的单晶。厚棱柱平板晶体属于空间群P2(1)2(1)2，晶胞尺寸为a = 177.42 Å，b = 37.36 Å和c = 73.30 Å。
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