Tanaka Natsuki, Izawa Takeshi, Yamate Jyoji, Kuwamura Mitsuru
Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka 598-8531, Japan.
J Toxicol Pathol. 2017 Jul;30(3):231-234. doi: 10.1293/tox.2017-0004. Epub 2017 Mar 24.
An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. In the fibrous connective tissue surrounding the nests, neoplastic cells with striations demonstrable by phosphotungstic acid hematoxylin were observed. Immunohistochemically, neoplastic stellate cells were partially positive for Wilms Tumor 1 and vimentin, and neoplastic cells with striations were partially positive for desmin. We diagnosed this tumor as a nephroblastoma with striated muscle differentiation. To our knowledge, this is the first case of nephroblastoma with apparent striated muscle differentiation in an F344 rat.
一只11个月大的雄性F344/DuCrj（F344）大鼠在尸检时被发现死亡，右肾有肿块。组织病理学检查显示，肿块由肿瘤性星状细胞巢组成。在巢的中心，肿瘤性上皮细胞形成管状结构。在巢周围的纤维结缔组织中，观察到经磷钨酸苏木精染色显示有横纹的肿瘤细胞。免疫组织化学检查显示，肿瘤性星状细胞对肾母细胞瘤1和波形蛋白呈部分阳性，有横纹的肿瘤细胞对结蛋白呈部分阳性。我们将此肿瘤诊断为具有横纹肌分化的肾母细胞瘤。据我们所知，这是F344大鼠中首例具有明显横纹肌分化的肾母细胞瘤病例。
