Yanagisawa Shuichi, Sudo Tomoko, Noyori Ryoji, Itami Kenichiro
Department of Chemistry and Research Center for Materials Science, Nagoya University, Nagoya 464-8602, Japan.
J Am Chem Soc. 2006 Sep 13;128(36):11748-9. doi: 10.1021/ja064500p.
A new method for the catalytic C-H arylation of heteroarenes and arenes that manifests high activity paired with reasonably broad scope was developed. Under the catalytic influence of RhCl(CO){P[OCH(CF3)2]3}2 and Ag2CO3, the direct C-H arylation of heteroarenes/arenes with aryl/heteroaryl iodides took place to afford a range of biaryls in good to excellent yields with high regioselectivity. Thiophenes, furans, pyrroles, indoles, and alkoxybenzenes are applicable in this arylation protocol.
开发了一种用于杂芳烃和芳烃催化C-H芳基化的新方法，该方法具有高活性且适用范围相当广泛。在RhCl(CO){P[OCH(CF3)2]3}2和Ag2CO3的催化作用下，杂芳烃/芳烃与芳基/杂芳基碘化物发生直接C-H芳基化反应，以良好至优异的产率和高区域选择性得到一系列联芳基化合物。噻吩、呋喃、吡咯、吲哚和烷氧基苯适用于该芳基化反应体系。
