通过烯醇盐合成多取代呋喃、吡咯和噻吩。
Synthesis of multisubstituted furans, pyrroles, and thiophenes via ynolates.
作者信息
Shindo Mitsuru, Yoshimura Yutaka, Hayashi Maiko, Soejima Hiroe, Yoshikawa Takashi, Matsumoto Kenji, Shishido Kozo
机构信息
Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Japan.
出版信息
Org Lett. 2007 May 10;9(10):1963-6. doi: 10.1021/ol0705200. Epub 2007 Apr 17.
PMID:17439135
Abstract
An efficient synthetic method for the preparation of multisubstituted furans, thiophenes, and pyrroles using ynolates was developed. This novel formal [4 + 1] annulation by C2-C3 and C3-C4 bond formations includes cycloaddition, cyclization, decarboxylation, and dehydration as key steps.
摘要
开发了一种使用烯醇盐制备多取代呋喃、噻吩和吡咯的有效合成方法。这种通过形成C2-C3和C3-C4键的新型形式上的[4 + 1]环化反应，关键步骤包括环加成、环化、脱羧和脱水。
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