小鼠对致病性研究中常用的鼠疫耶尔森菌Δpgm菌株天然具有抗性。
Mice naturally resistant to Yersinia pestis Delta pgm strains commonly used in pathogenicity studies.
作者信息
Congleton Yasemin H K, Wulff Christine R, Kerschen Edward J, Straley Susan C
机构信息
Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536-0298, USA.
出版信息
Infect Immun. 2006 Nov;74(11):6501-4. doi: 10.1128/IAI.00597-06. Epub 2006 Sep 5.
Abstract
We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Deltapgm strains of Yersinia pestis; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.
摘要
我们报告称，近交系小鼠品系129的一些亚系雌性对由鼠疫耶尔森氏菌的条件性减毒株引起的全身性鼠疫具有抗性；然而，完全有毒力的鼠疫耶尔森氏菌在这些小鼠中并未减毒。因此，这些小鼠提供了一个强大的系统，可用于并行绘制鼠疫的宿主抗性性状和相对的细菌毒力特性。
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