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Absence of inflammation and pneumonia during infection with nonpigmented Yersinia pestis reveals a new role for the pgm locus in pathogenesis.在感染非色素鼠疫耶尔森菌期间没有炎症和肺炎，这揭示了 pgm 基因座在发病机制中的新作用。
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Substrains of 129 mice are resistant to Yersinia pestis KIM5: implications for interleukin-10-deficient mice.129小鼠的亚系对鼠疫耶尔森氏菌KIM5具有抗性：对白介素-10缺陷小鼠的启示
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本文引用的文献

1
Replication of Yersinia pestis in interferon gamma-activated macrophages requires ripA, a gene encoded in the pigmentation locus.鼠疫耶尔森菌在干扰素γ激活的巨噬细胞中的复制需要ripA，这是一个位于色素沉着位点的编码基因。
Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12909-14. doi: 10.1073/pnas.0502849102. Epub 2005 Aug 24.
2
Antibody against V antigen prevents Yop-dependent growth of Yersinia pestis.抗V抗原的抗体可阻止鼠疫耶尔森菌依赖Yop的生长。
Infect Immun. 2005 Mar;73(3):1532-42. doi: 10.1128/IAI.73.3.1532-1542.2005.
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Transmission of Yersinia pestis from an infectious biofilm in the flea vector.鼠疫耶尔森菌从跳蚤媒介中的感染性生物膜传播。
J Infect Dis. 2004 Aug 15;190(4):783-92. doi: 10.1086/422695. Epub 2004 Jul 12.
4
The plague virulence protein YopM targets the innate immune response by causing a global depletion of NK cells.鼠疫毒力蛋白YopM通过导致自然杀伤细胞全面减少来靶向先天免疫反应。
Infect Immun. 2004 Aug;72(8):4589-602. doi: 10.1128/IAI.72.8.4589-4602.2004.
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Evolutionary genetics: CCR5 mutation and plague protection.
Nature. 2004 Feb 12;427(6975):606. doi: 10.1038/427606a.
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Granulocyte function in grancalcin-deficient mice.粒钙蛋白缺陷小鼠的粒细胞功能。
Mol Cell Biol. 2003 Feb;23(3):826-30. doi: 10.1128/MCB.23.3.826-830.2003.
7
The Yersinia Ysc-Yop 'type III' weaponry.耶尔森氏菌的Ysc-Yop“III型”武器装备。
Nat Rev Mol Cell Biol. 2002 Oct;3(10):742-52. doi: 10.1038/nrm932.
8
Protection conferred by a fully recombinant sub-unit vaccine against Yersinia pestis in male and female mice of four inbred strains.
Vaccine. 2000 Sep 15;19(2-3):358-66. doi: 10.1016/s0264-410x(00)00108-0.
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Yersinia pestis--etiologic agent of plague.鼠疫耶尔森菌——鼠疫的病原体。
Clin Microbiol Rev. 1997 Jan;10(1):35-66. doi: 10.1128/CMR.10.1.35.
10
In vivo comparison of avirulent Vwa- and Pgm- or Pstr phenotypes of yersiniae.耶尔森氏菌无毒Vwa、Pgm或Pstr表型的体内比较
Infect Immun. 1984 Mar;43(3):895-900. doi: 10.1128/iai.43.3.895-900.1984.

小鼠对致病性研究中常用的鼠疫耶尔森菌Δpgm菌株天然具有抗性。

Mice naturally resistant to Yersinia pestis Delta pgm strains commonly used in pathogenicity studies.

作者信息

Congleton Yasemin H K, Wulff Christine R, Kerschen Edward J, Straley Susan C

机构信息

Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536-0298, USA.

出版信息

Infect Immun. 2006 Nov;74(11):6501-4. doi: 10.1128/IAI.00597-06. Epub 2006 Sep 5.

DOI:10.1128/IAI.00597-06
PMID:16954401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1695521/
Abstract

We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Deltapgm strains of Yersinia pestis; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.

摘要

我们报告称，近交系小鼠品系129的一些亚系雌性对由鼠疫耶尔森氏菌的条件性减毒株引起的全身性鼠疫具有抗性；然而，完全有毒力的鼠疫耶尔森氏菌在这些小鼠中并未减毒。因此，这些小鼠提供了一个强大的系统，可用于并行绘制鼠疫的宿主抗性性状和相对的细菌毒力特性。