Masini E, Bianchi S, Gambassi F, Palmerani B, Pistelli A, Carlomagno L, Mannaioni P F
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
Agents Actions. 1990 Apr;30(1-2):198-201. doi: 10.1007/BF01969037.
Experiments were carried out to provide further information on the biochemical and morphological changes occurring in the guinea-pig heart after multiple ligature and reopening of the left anterior descending (LAD) coronary artery. In isolated perfused guinea-pig heart the reopening of LAD coronary artery leads to a release of histamine related to a loss of metachromasia by cardiac mast cells. The process is associated with malonyldialdehyde (MDA) production, cellular overload of calcium and ventricular arrhythmias which can be modulated by pharmacological interventions.
进行了实验，以提供更多关于豚鼠心脏在多次结扎和重新开放左前降支（LAD）冠状动脉后发生的生化和形态学变化的信息。在离体灌注的豚鼠心脏中，LAD冠状动脉的重新开放导致组胺释放，这与心脏肥大细胞异染性的丧失有关。该过程与丙二醛（MDA）的产生、细胞钙超载和室性心律失常有关，这些可通过药物干预进行调节。
