Oosting E, Kardaun S H, Doeglas H M, Los P, de Monchy J G
B.C.O. Centre for Research, Breda, The Netherlands.
Agents Actions. 1990 Apr;30(1-2):254-7. doi: 10.1007/BF01969053.
Seventeen chronic urticaria patients with a history suggestive of acetylsalicylic acid (ASA, Aspirin)-intolerance were challenged with ASA; only 2 patients showed marked clinical reactions. These clinical reactions were accompanied by a significant increase in the urinary excretion of the most important histamine metabolite, N tau-methylhistamine, in comparison with 15 non-responders (p less than or equal to 0.05) and placebo test. These results suggest an involvement of histamine in the pathogenesis of ASA-intolerance in chronic urticaria patients.
17名有乙酰水杨酸（ASA，阿司匹林）不耐受病史的慢性荨麻疹患者接受了ASA激发试验；只有2名患者出现明显的临床反应。与15名无反应者及安慰剂试验相比，这些临床反应伴随着最重要的组胺代谢产物N-τ-甲基组胺尿排泄量的显著增加（p≤0.05）。这些结果提示组胺参与了慢性荨麻疹患者ASA不耐受的发病机制。
