Peled Nir, Shitrit David, Bendayan Daniele, Peled Eli, Kramer Mordechai R
Pulmonary Institute, Rabin Medical Center, Beilinson Campus, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Respiration. 2007;74(1):50-5. doi: 10.1159/000095675. Epub 2006 Sep 5.
Although certain studies report high levels of vascular endothelial growth factor (VEGF) in obstructive sleep apnea syndrome (OSAS), the effect of systemic hypoxia on circulating VEGF remains controversial.
To study the association of serum VEGF and OSAS in a large group of patients.
One hundred patients with OSAS (mean age 58.1+/-12.4 years, mean body mass index 30.6+/-5.4 kg/m2) were tested for serum VEGF levels, and the findings were correlated with the severity of OSAS, as determined by the apnea-hypopnea index (AHI) on the basis of polysomnography and background data.
The mean AHI was 40.0+/-21.2 (range 10-106). Mean minimal oxygen saturation was 80.6+/-11.7% (range 43-98%) and mean time of oxygen saturation under 90% was 50.0+/-75.0 min (range 0-300 min). The mean VEGF level was 445.2+/-289.8 pg/ml in the study group (vs. 280 pg/ml reported in normal controls). The mean platelet count was 233.8+/-64.4 10(3)/ml and the mean VEGF/platelet ratio was 1.95+/-1.40 pg/10(6). There was no association of VEGF or VEGF/platelets with the severity of OSAS. However, both factors showed a significant correlation with patient age (r=0.224, p=0.01 and r=0.425, p=0.01, respectively). Age was the only parameter to significantly predict VEGF and VEGF/platelets on multivariate analysis (R2=0.713, p=0.001 and R2=0.844, p=0.001, respectively).
The elevation of serum VEGF in OSAS is not associated with the severity of the disease, but it is associated with patient age. VEGF might be involved in the long-term adaptive mechanism in OSAS, and its age-dependent increase might partly explain the reduced mortality in elderly OSAS patients.
尽管某些研究报告阻塞性睡眠呼吸暂停综合征（OSAS）患者血管内皮生长因子（VEGF）水平较高，但全身缺氧对循环VEGF的影响仍存在争议。
在一大组患者中研究血清VEGF与OSAS的关联。
检测100例OSAS患者（平均年龄58.1±12.4岁，平均体重指数30.6±5.4kg/m²）的血清VEGF水平，并将结果与基于多导睡眠图和背景数据的呼吸暂停低通气指数（AHI）所确定的OSAS严重程度相关联。
平均AHI为40.0±21.2（范围10 - 106）。平均最低血氧饱和度为80.6±11.7%（范围43 - 98%），血氧饱和度低于90%的平均时间为50.0±75.0分钟（范围0 - 300分钟）。研究组的平均VEGF水平为445.2±289.8pg/ml（正常对照报道为280pg/ml）。平均血小板计数为233.8±64.4×10³/ml，平均VEGF/血小板比值为1.95±1.40pg/10⁶。VEGF或VEGF/血小板与OSAS严重程度无关。然而，这两个因素均与患者年龄显著相关（分别为r = 0.224，p = 0.01和r = 0.425，p = 0.01）。在多变量分析中，年龄是唯一能显著预测VEGF和VEGF/血小板的参数（分别为R² = 0.713，p = 0.001和R² = 0.844，p = 0.001）。
OSAS患者血清VEGF升高与疾病严重程度无关，但与患者年龄有关。VEGF可能参与OSAS的长期适应性机制，其随年龄增长的增加可能部分解释老年OSAS患者死亡率降低的原因。
