Piggins Hugh D
Faculty of Life Sciences, University of Manchester, 3.614 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Biochem J. 2006 Oct 1;399(1):e1-2. doi: 10.1042/BJ20061211.
Biological timekeeping is determined by internal temporal programmes and the resetting of these programmes or clocks by external stimuli. Many of the core genes of the mammalian daily or circadian clock are known, but the factors regulating so-called 'clock' gene proteins are unclear. In this issue of the Biochemical Journal, Gallego and colleagues show for the first time that protein phosphatase 1 plays a major role in the stability of mammalian PER2, a key protein in the core clock works. This contrasts somewhat with circadian rhythm control in the fruitfly Drosophila and the fungus Neurospora where current evidence supports a role for protein phosphatase 2A in core timekeeping. The mechanisms underpinning these actions of phosphatase 1 are unclear, and future investigations will need to identify the regulatory subunit that targets phosphatase 1 to mammalian PER2 (Period 2).
生物计时由内部时间程序以及这些程序或时钟受外部刺激的重置所决定。哺乳动物日常或昼夜节律时钟的许多核心基因已为人所知，但调节所谓“时钟”基因蛋白的因素尚不清楚。在本期《生物化学杂志》中，加列戈及其同事首次表明，蛋白磷酸酶1在哺乳动物PER2（核心生物钟中的一种关键蛋白）的稳定性中起主要作用。这在一定程度上与果蝇和真菌脉孢菌中的昼夜节律控制形成对比，在果蝇和真菌脉孢菌中，目前的证据支持蛋白磷酸酶2A在核心计时中发挥作用。磷酸酶1这些作用的潜在机制尚不清楚，未来的研究需要确定将磷酸酶1靶向哺乳动物PER2（周期蛋白2）的调节亚基。
