Sindjelic Radomir, Davidovic Lazar, Vlajkovic Gordana, Markovic Miroslav, Kuzmanović Ilija
Department of Ophthalmic Anesthesia, Institute for Anesthesia and Reanimation, Clinical Centre of Serbia, Belgrade, Serbia and Montenegro.
Vascular. 2006 Mar-Apr;14(2):75-80. doi: 10.2310/6670.2006.00013.
Carotid artery surgery (CAS) performed under cervical plexus block is frequently associated with significant intra- and postoperative pain. To evaluate whether preoperative administration of ketorolac may improve analgesia in this type of surgery, 80 patients scheduled for CAS under cervical plexus block were randomly allocated to receive intravenously either 30 mg of ketorolac or placebo 30 minutes before surgery. Verbal rating scale pain scores during surgery and 3 and 6 hours after surgery, the number of patients requiring additional analgesia, and the total analgesic consumption both during and within 6 hours after surgery were significantly lower, whereas the time to first postoperative analgesia was significantly shorter in the ketorolac group than in the control group. The results of this prospective, randomized, double-blind study show that a single 30 mg dose of ketorolac administered intravenously 30 minutes before surgery reduces intraoperative pain and preempts postoperative pain in patients undergoing CAS under carotid plexus block.
在颈丛阻滞下进行的颈动脉手术（CAS）常常伴有明显的术中及术后疼痛。为评估术前给予酮咯酸是否可改善此类手术中的镇痛效果，80例计划在颈丛阻滞下接受CAS的患者被随机分配，于手术前30分钟静脉注射30毫克酮咯酸或安慰剂。酮咯酸组术中及术后3小时和6小时的语言评定量表疼痛评分、需要额外镇痛的患者数量以及手术期间和术后6小时内的总镇痛药物消耗量均显著更低，而术后首次镇痛的时间显著短于对照组。这项前瞻性、随机、双盲研究的结果表明，手术前30分钟静脉注射单次30毫克剂量的酮咯酸可减轻接受颈丛阻滞下CAS患者的术中疼痛并预防术后疼痛。
