肿瘤坏死因子-α及其受体在星形胶质细胞产生神经生长因子和胶质细胞源性神经营养因子中的作用。
The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes.
作者信息
Kuno Reiko, Yoshida Yusuke, Nitta Atsumi, Nabeshima Toshitaka, Wang Jinyan, Sonobe Yoshifumi, Kawanokuchi Jun, Takeuchi Hideyuki, Mizuno Tetsuya, Suzumura Akio
机构信息
Department of Neuroimmunology, Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
出版信息
Brain Res. 2006 Oct 20;1116(1):12-8. doi: 10.1016/j.brainres.2006.07.120. Epub 2006 Sep 7.
The neurotrophic factors, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), are produced by astrocytes, and are induced by inflammatory stimuli including bacterial lipopolysaccharide and pro-inflammatory cytokines. In this study, we examined the regulatory mechanisms of tumor necrosis factor-alpha (TNF-alpha)-induced production of neurotrophic factors. We show here that cultured astrocytes express both TNF-alpha receptor 1 (TNFR1) and TNFR2, and that activation of these receptors by TNF-alpha promotes expression of both NGF and GDNF. In addition, we observe that not only exogenous TNF-alpha but also TNF-alpha produced by astrocytes induce NGF and GDNF production in astrocytes. These results suggest that an autocrine loop involving TNF-alpha contributes to the production of neurotrophic factors in response to inflammation.
神经营养因子，即神经生长因子（NGF）和胶质细胞系源性神经营养因子（GDNF），由星形胶质细胞产生，并由包括细菌脂多糖和促炎细胞因子在内的炎症刺激所诱导。在本研究中，我们检测了肿瘤坏死因子-α（TNF-α）诱导神经营养因子产生的调控机制。我们在此表明，培养的星形胶质细胞表达TNF-α受体1（TNFR1）和TNFR2，并且TNF-α对这些受体的激活促进了NGF和GDNF的表达。此外，我们观察到，不仅外源性TNF-α，而且星形胶质细胞产生的TNF-α也能诱导星形胶质细胞中NGF和GDNF的产生。这些结果表明，涉及TNF-α的自分泌环有助于在炎症反应中产生神经营养因子。
Zotero 插件