Alkhatib Ala, Biebel Ulrich W, Smolders Jean W T
Physiology II, JW Goethe-University, Frankfurt am Main, Germany.
Neuroreport. 2006 Oct 2;17(14):1493-7. doi: 10.1097/01.wnr.0000234754.11431.ee.
Effects of carboplatin-induced partial loss of inner hair cells on rate-level functions of neurons in the central nucleus of the inferior colliculus of the same chinchillas before and 1-3 months after carboplatin treatment were examined. Partial inner hair cell loss caused only a small elevation of response thresholds but induced a significant increase in the proportion of monotonic and a significant decrease in the proportion of non-monotonic rate-level functions at the characteristic frequency of 210 multiunits. This indicates that inhibition in the inferior colliculus is reduced after sensory deafferentation. We conclude that some of the functional changes reported in the auditory cortex after peripheral deafferentation are already realized at the level of the inferior colliculus.
研究了卡铂诱导的内耳毛细胞部分缺失对同一组毛丝鼠在卡铂治疗前及治疗后1 - 3个月下丘中央核神经元速率-强度函数的影响。内耳毛细胞部分缺失仅导致反应阈值略有升高，但在210个多单位的特征频率处，单调速率-强度函数的比例显著增加，非单调速率-强度函数的比例显著降低。这表明感觉传入缺失后下丘的抑制作用减弱。我们得出结论，外周传入缺失后听觉皮层中报道的一些功能变化在下丘水平已经出现。
