Wake M, Takeno S, Ibrahim D, Harrison R
Department of Otolaryngology, Hospital for Sick Children, Toronto, Canada.
Laryngoscope. 1994 Apr;104(4):488-93. doi: 10.1288/00005537-199404000-00016.
Carboplatin is a second-generation platinum antineoplastic agent. It has biological activity similar to cisplatin and is currently recommended for the treatment of ovarian cancer. In clinical use, carboplatin appears less ototoxic than cisplatin. This paper reports the ototoxic effects of carboplatin, in doses equivalent to the clinical use of the drug, in the chinchilla. Intravenous carboplatin 200 to 400 mg/m2 by bolus injection caused significant ototoxicity in this model as revealed by brainstem evoked responses (ABR audiometry). The cochlear pathology as seen by scanning electron microscopy revealed predominantly inner hair cell (IHC) stereocilia damage. Furthermore, the extent (grade) of the morphological lesions appears to be well correlated with the auditory brainstem response pattern of threshold elevation.
卡铂是第二代铂类抗肿瘤药物。它具有与顺铂相似的生物活性，目前被推荐用于治疗卵巢癌。在临床应用中，卡铂的耳毒性似乎比顺铂小。本文报道了在栗鼠身上使用等同于临床用药剂量的卡铂所产生的耳毒性作用。通过大剂量注射静脉给予卡铂200至400mg/m²，在此模型中诱发了明显的耳毒性，这可通过脑干诱发电位（ABR听力测定）显示出来。扫描电子显微镜观察到的耳蜗病理主要表现为内毛细胞（IHC）静纤毛损伤。此外，形态学损伤的程度（分级）似乎与阈值升高的听觉脑干反应模式密切相关。
