Hazza'a Abdalla M, Al-Jamal Ghaida
Department of Oral Medicine and Oral Surgery of the Faculty of Dentistry at the Jordan University of Science and Technology in Irbid, Jordan.
J Contemp Dent Pract. 2006 Sep 1;7(4):63-70.
The aim of this study was to evaluate the dental development of patients with ss-thalassemia major and to compare it with unaffected children.
Panoramic radiographs of 44 thalassemic patients taken before the age of 16 years were examined. The subjects consisted of 29 males and 15 females ranging in age from 4.9 to 15.7 (mean = 10.8+/-2.9) years and 44 controls matched for age and sex. The seven left mandibular permanent teeth, second molar to central incisor, were rated on an eight stage scale using the methods described by Demirjian et al.10 The stage of each tooth was converted to the corresponding numeric value and then all values were added to obtain a dental maturity score which corresponded to a dental age. Dental and chronologic ages were compared using a paired t-test. The relationship between the chronologic age and the amount of delay was also determined.
Thirty-nine patients had a delay in the development of their dentition. The mean developmental dental delay was found to be 1.01 years (p<0.05). The range in delay was from 0.1 to 2.9 years. There was no significant difference between the mean chronologic and dental age of the control group (p> 0.05). The amount of delay in dental development increases as the patient's age increased (p<0.05). Males were found to have a greater delay (mean 1.16 years) than females (mean delay 0.73 years), but this difference was not statistically significant.
The delay in dental development in ss-thalassemia major varied according to the patient's age. This positive correlation parallels the general growth of thalassemic children.
本研究旨在评估重型β地中海贫血患者的牙齿发育情况，并与未受影响的儿童进行比较。
对44例16岁之前拍摄的重型地中海贫血患者的全景X线片进行检查。研究对象包括29例男性和15例女性，年龄在4.9至15.7岁之间（平均 = 10.8±2.9岁），以及44例年龄和性别匹配的对照者。使用Demirjian等人描述的方法，对左侧下颌七颗恒牙（从第二磨牙到中切牙）按照八阶段量表进行评分。将每颗牙齿的阶段转换为相应的数值，然后将所有数值相加，以获得与牙齿年龄相对应的牙齿成熟度评分。使用配对t检验比较牙齿年龄和实际年龄。还确定了实际年龄与延迟量之间的关系。
39例患者的牙列发育延迟。发现平均发育性牙齿延迟为1.01年（p<0.05）。延迟范围为0.1至2.9年。对照组的平均实际年龄和牙齿年龄之间无显著差异（p>0.05）。牙齿发育延迟量随着患者年龄的增加而增加（p<0.05）。发现男性的延迟更大（平均1.16年），高于女性（平均延迟0.73年），但这种差异无统计学意义。
重型β地中海贫血患者的牙齿发育延迟因患者年龄而异。这种正相关与地中海贫血儿童的总体生长情况相似。
