Hattab Faiez N
Private Practice, Family Dental Clinic, Doha, Qatar.
J Oral Sci. 2013 Mar;55(1):71-7. doi: 10.2334/josnusd.55.71.
Dental development and physical growth are of particular interest in pediatric dentistry and orthodontics. This study evaluated these variables in patients with thalassemia major (TM). Physical growth was assessed in 54 patients (31 males and 23 females) aged 5.5 to 18.3 years and dental development was analyzed using panoramic radiographs from 39 of the 54 patients. The Demirjian system was used to characterize dental development of the seven left mandibular permanent teeth. Chronologic age (CA) and dental age (DA) were compared using the paired t-test, and the correlation between CA and extent of delay in dental development (DA minus CA) was assessed using Pearson's correlation coefficients. Growth retardation (< 10th percentile for height and weight) was present in 75.9% of TM patients. Height less than the third percentile was noted in 41.9% (13/31) of males and 34.8% (8/23) of females. Mean (SD) body mass index was 16.5 ± 2.2 kg/m(2). The extent of growth retardation increased with advancing age. Patient radiographs revealed a delay in dental development in 31 of 39 (79.5%) of participants (mean delay, 1.12 years in males and 0.81 years in females; range, 0.1 to 2.7 years). The mean difference between CA and DA was 0.97 years (P < 0.001). CA was significant correlated with extent of dental developmental delay (r = 0.64, P < 0.01). The results show that, among children and adolescents with TM, the proportions of those who had short stature, were underweight, and had a low growth rate increased with age. In addition, participants had significant delays in dental development.
牙齿发育和身体生长在儿童牙科和正畸学中备受关注。本研究评估了重型地中海贫血（TM）患者的这些变量。对54例年龄在5.5至18.3岁的患者（31例男性和23例女性）进行了身体生长评估，并使用54例患者中39例的全景X线片分析了牙齿发育情况。采用德米尔坚系统对左侧下颌七颗恒牙的牙齿发育进行表征。使用配对t检验比较实际年龄（CA）和牙龄（DA），并使用Pearson相关系数评估CA与牙齿发育延迟程度（DA减去CA）之间的相关性。75.9%的TM患者存在生长发育迟缓（身高和体重低于第10百分位数）。41.9%（13/31）的男性和34.8%（8/23）的女性身高低于第3百分位数。平均（标准差）体重指数为16.5±2.2kg/m²。生长发育迟缓的程度随着年龄的增长而增加。患者的X线片显示，39名参与者中有31名（79.5%）存在牙齿发育延迟（男性平均延迟1.12年，女性平均延迟0.81年；范围为0.1至2.7年）。CA与DA之间的平均差异为0.97年（P<0.001）。CA与牙齿发育延迟程度显著相关（r=0.64，P<0.01）。结果表明，在患有TM的儿童和青少年中，身材矮小、体重不足和生长速度低的比例随年龄增加。此外，参与者的牙齿发育存在显著延迟。
