Hirao J, Hibi S, Andoh T, Ichimura T
First Department of Pediatrics, Dokkyo University School of Medicine.
Arerugi. 1996 Oct;45(10):1137-9.
We have measured the plasma levels of IL-4 in patients with Kawasaki disease, serially. The results were as follows: The plasma levels of IL-4 from patients with Kawasaki disease in acute phase (median 17 pg/ml) were significantly higher than those from the patients in convalescent phase (median 1.96 pg/ ml, p = 0.001) or from control children (median 7.64 pg/ml, p = 0.001). These findings imply that Th2 (or Tho) cells may be vigorously stimulated at an acute phase of this disease, and that IL-4 produced by these cells may possibly modulate the pathological conditions of this disease.
我们连续测量了川崎病患者的血浆白细胞介素-4（IL-4）水平。结果如下：急性期川崎病患者的血浆IL-4水平（中位数为17 pg/ml）显著高于恢复期患者（中位数为1.96 pg/ml，p = 0.001）或对照儿童（中位数为7.64 pg/ml，p = 0.001）。这些发现表明，在该疾病的急性期，Th2（或Th0）细胞可能受到强烈刺激，并且这些细胞产生的IL-4可能会调节该疾病的病理状况。
