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[Comparative inhibitory analysis of DNA biosynthesis catalyzed by retrovirus reverse transcriptase].

作者信息

Kileso T Iu, Tarusova N B, Atrazheva E D, Kukhanova M K, Shulenin S V, Bobkov A F, Garaev M M, Galegov G A, Kraevskiĭ A A

出版信息

Bioorg Khim. 1990 Apr;16(4):531-6.

PMID:1695849
Abstract

Comparative study of DNA biosynthesis inhibition, catalyzed by avian myeloblastose virus (AMV) reverse transcriptase (RT), human immunodeficiency virus (HIV) recombinant and native RT, has been performed. 3'-Azido-2',3'-dideoxythymidine 5'-triphosphate (AzTTP); 3'-azido-2',3'-dideoxythymidine 5'-methylenephosphonate-diphosphate: 3'-azido-2',3'-dideoxythymidine 5'-phosphate-phosponoacetate; 3'-azido-2',3'-dideoxythymidine 5'-phosphate-dibromomethylenephosphonate; 2',3'-O-isopropylidenecytidine 5'-methylenephosphonate-diphosphate (rC-IP-MPDP) were used as inhibitors. AzTTP proved to by the most active inhibitor (its activity against HIV RT is higher than against AMV RT), although not selective as the phosphonates; only rC-iP-MPDP has low selectivity.

摘要

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