Custodio Hipolito M, Harari Raul, Gerhardsson Lars, Skerfving Staffan, Broberg Karin
Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden.
Arch Environ Occup Health. 2005 Jan-Feb;60(1):17-23. doi: 10.3200/AEOH.60.1.17-23.
Mercury is eliminated as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL), and conjugation by glutathione S-transferases (GST). This study tested if polymorphisms in GCL and GST genes modify mercury retention in humans exposed to elemental mercury vapor. Total mercury concentrations in whole blood, plasma and urine, and genotypes for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 309 gold miners, gold buyers and controls. The presence of the GCLM-588T allele was associated with increased blood, plasma and urine mercury levels. These results indicate that genotypes with decreased GSH availability for mercury conjugation affect the metabolism of inorganic mercury.
汞以谷胱甘肽（GSH）共轭物的形式被清除。谷胱甘肽的产生由谷氨酰半胱氨酸连接酶（GCL）介导，而共轭作用则由谷胱甘肽S-转移酶（GST）介导。本研究检测了GCL和GST基因中的多态性是否会改变暴露于元素汞蒸气的人体中的汞潴留情况。测定了309名金矿工人、黄金买家和对照组的全血、血浆和尿液中的总汞浓度，以及GCLC、GCLM、GSTA1、GSTM1、GSTP1和GSTT1的基因型。GCLM - 588T等位基因的存在与血液、血浆和尿液中汞水平的升高有关。这些结果表明，用于汞共轭的谷胱甘肽可用性降低的基因型会影响无机汞的代谢。
