Clinical Molecular Biology Laboratory, Dept. of Laboratory Medicine, PTV, Rome, Italy.
Psychiatry Res. 2011 May 30;187(3):454-6. doi: 10.1016/j.psychres.2010.10.008. Epub 2010 Nov 18.
Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.
氧化损伤被认为在精神分裂症的易感性中起作用。我们确定了 GSTP1、GSTM1、GSTT1 和 GSTA1 基因的多态性是否作为精神分裂症的易感基因，这些基因影响这些酶对氧化应激的活性，分析了 138 名精神分裂症患者和 133 名健康对照者。我们发现，GSTM1 基因缺失与 GSTM1 基因多态性 GSTA1*B/*B 结合，以及 GSTT1 基因的存在，是精神分裂症的危险因素，表明不同 GST 多态性的组合在精神分裂症的易感性中起作用，可能影响细胞解毒儿茶酚胺氧化代谢物的能力。
