Legout L, Senneville E, Stern R, Yazdanpanah Y, Savage C, Roussel-Delvalez M, Rosele B, Migaud H, Mouton Y
Division of Infectious Diseases, University of Lille, Dron Hospital, Tourcoing, France.
Clin Microbiol Infect. 2006 Oct;12(10):1030-3. doi: 10.1111/j.1469-0691.2006.01523.x.
A 3-year retrospective study evaluated the effectiveness and safety of cefepime plus a fluoroquinolone for treating bone and joint infections caused by Gram-negative bacilli (GNB) in 28 patients. Intra-operative cultures yielded primarily Pseudomonas spp. and Enterobacter cloacae. Full recovery (cure) was observed in 79% of patients. There were no serious adverse effects and no resistant organisms were isolated. The results of the study confirmed the safety and effectiveness of cefepime combined with a fluoroquinolone for the treatment of bone and joint infections caused by Gram-negative bacilli.
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