Belliveau P, Nightingale C H, Quintiliani R, Crowe H, Gousee G
Hartford Hospital.
Conn Med. 1993 Aug;57(8):539-45.
Ciprofloxacin, ofloxacin, and lomefloxacin are oral fluoroquinolones with ideal characteristics for oral antimicrobial therapy. These agents provide 1) appropriate and reliable serum concentrations, 2) broad antimicrobial activity, 3) proven efficacy in the treatment of serious infections, and 4) good tolerability. Although cations decrease the absorption of these drugs, there are proven means of avoiding these interactions. Therefore, these agents could easily be utilized as alternatives to prolonged intravenous treatment of many infectious diseases in patients who do not have conditions which impair drug absorption.
环丙沙星、氧氟沙星和洛美沙星是口服氟喹诺酮类药物，具有口服抗菌治疗的理想特性。这些药物具有以下特点：1）血清浓度适宜且可靠；2）抗菌活性广泛；3）在治疗严重感染方面已证实有效；4）耐受性良好。尽管阳离子会降低这些药物的吸收，但已有避免这些相互作用的可靠方法。因此，对于没有影响药物吸收情况的患者，这些药物可轻松用作许多传染病长期静脉治疗的替代药物。
