Stange E F
Abteilung für Innere Medizin 1 Schwerpunkte Gastroenterologie, Hepatologie und Endokrinologie, Robert Bosch Krankenhaus, Stuttgart, Germany.
Aliment Pharmacol Ther. 2006 Oct;24 Suppl 3:64-7. doi: 10.1111/j.1365-2036.2006.03063.x.
Ulcerative colitis and, maybe to a similar extent, Crohn's disease are associated with an increased risk of colorectal carcinoma. As a consequence of this increased risk, surveillance strategies have been proposed to prevent colorectal carcinoma through early detection of dysplasia, which may herald malignant disease. These surveillance strategies are controversial for several reasons discussed in this review. It may be concluded from the relevant studies that regular use of at least 1.2 g of mesalazine per day may effectively prevent about two out of three colon cancers in ulcerative colitis. In contrast, there seems to be no role for either mercaptopurine or folic acid in protection from colon cancer.
溃疡性结肠炎，或许在相似程度上，克罗恩病与结直肠癌风险增加相关。鉴于这种风险增加，已提出监测策略，旨在通过早期发现发育异常来预防结直肠癌，因为发育异常可能预示着恶性疾病。这些监测策略存在争议，原因将在本综述中讨论。从相关研究可以得出结论，溃疡性结肠炎患者每天规律服用至少1.2克美沙拉嗪可能有效预防约三分之二的结肠癌。相比之下，巯嘌呤或叶酸在预防结肠癌方面似乎并无作用。
