Youinou P, Le Goff P, Dumay A, Lelong A, Fauquert P, Jouquan J
Department of Immunology, Brest University Medical School Hospital, France.
Clin Exp Rheumatol. 1990 May-Jun;8(3):259-64.
The antiperinuclear factor (APF) test raises two main problems: the unpredictability of the cells used as substrate and the difficulty in expressing the results. We propose that 10% of the cells have to be stained by a given serum in order for it to be considered positive. APF were found to be present in 76% of rheumatoid arthritis (RA) patients, 3% of healthy controls and occasionally in disease controls. The production of APF was significantly (p less than 0.01) related to the presence of rheumatoid factor in RA, and IgG antibody was predominant in the APF test.
抗核周因子（APF）检测存在两个主要问题：用作底物的细胞不可预测性以及结果表达的困难。我们建议，若某种血清能使10%的细胞染色，则该血清应被视为呈阳性。研究发现，76%的类风湿关节炎（RA）患者体内存在APF，健康对照者中这一比例为3%，疾病对照者中偶尔也会出现。在RA患者中，APF的产生与类风湿因子的存在显著相关（p<0.01），且在APF检测中IgG抗体占主导地位。
