Westgeest A A, Boerbooms A M, Jongmans M, Vandenbroucke J P, Vierwinden G, van de Putte L B
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
J Rheumatol. 1987 Oct;14(5):893-7.
The specificity of antiperinuclear factor (APF) for patients with rheumatoid arthritis (RA) is well documented. It is unknown whether detection of these antibodies adds information to the detection of rheumatoid factor (RF). In a group of 132 patients with RA, 94 were RF positive. Of the 38 patients persistently negative for RF, 14 (37%) were positive for APF. These 14 proved to have a disease course similar to that of RF positive patients. This similarity was shown most impressively by radiological progression of the disease, and to a lesser extent, by the medication needed to control the disease and the number of extraarticular manifestations. No significant correlation was shown between APF and antinuclear antibodies. Among the RF positive patients with their generally poorer prognosis, APF identified the worst affected. Our study suggests that APF in serum of patients with RA is associated with a poor disease outcome, especially in RF negative patients.
抗核周因子（APF）对类风湿关节炎（RA）患者的特异性已有充分文献记载。这些抗体的检测是否能为类风湿因子（RF）的检测提供更多信息尚不清楚。在一组132例RA患者中，94例RF呈阳性。在38例RF持续阴性的患者中，14例（37%）APF呈阳性。这14例患者的病程与RF阳性患者相似。这种相似性在疾病的放射学进展中表现得最为明显，在较小程度上，体现在控制疾病所需的药物以及关节外表现的数量上。APF与抗核抗体之间未显示出显著相关性。在预后通常较差的RF阳性患者中，APF识别出病情最严重的患者。我们的研究表明，RA患者血清中的APF与不良疾病转归相关，尤其是在RF阴性患者中。
