Macdonald Christopher J, Meck Warren H
Department of Psychology and Neuroscience, Genome Sciences Research Building II, 3rd Floor, 572 Research Drive, Box 91050, Duke University, Durham, NC 27708, United States.
Behav Brain Res. 2006 Nov 25;175(1):62-74. doi: 10.1016/j.bbr.2006.08.004. Epub 2006 Sep 7.
In a series of three experiments, simple reaction time (RT) was characterized with respect to a variable preparatory interval (PI) in order to investigate the relationship between interval timing and RT. In Experiment 1, it was shown that RT decreases as a function of PI and that this effect varies with amount of training. In Experiment 2, RT was shown to increase during probe trials that used a novel 6.25s PI, suggesting that the specific durations of the PIs encoded during initial training contribute to the PI effect on RT. In Experiment 3, 100 microg/kg i.p. of raclopride proportionally slowed RT as a function of the PI. These results are discussed within the context of neuropsychological models of interval timing and support an underlying role for cortico-striatal dopaminergic function in temporal processing and simple RT measurements.
在一系列三个实验中，为了研究间隔计时与简单反应时（RT）之间的关系，对简单反应时进行了关于可变准备间隔（PI）的特征描述。在实验1中，结果表明反应时随准备间隔的增加而减少，并且这种效应随训练量而变化。在实验2中，发现在使用新的6.25秒准备间隔的探测试验中反应时增加，这表明在初始训练期间编码的准备间隔的特定时长对反应时的准备间隔效应有影响。在实验3中，腹腔注射100微克/千克的雷氯必利会根据准备间隔成比例地减慢反应时。这些结果在间隔计时的神经心理学模型背景下进行了讨论，并支持皮质-纹状体多巴胺能功能在时间处理和简单反应时测量中的潜在作用。
