Chen Xiaohua, Wen Wei, Anstey Kaarin J, Sachdev Perminder S
School of Psychiatry, University of New South Wales, Sydney, Australia.
Psychiatry Res. 2006 Oct 30;147(2-3):105-14. doi: 10.1016/j.pscychresns.2006.01.009. Epub 2006 Sep 7.
The effect of putative cerebrovascular risk factors on gray matter volume in a community-dwelling, non-demented 60- to 64-year-old cohort was investigated. Cranial T1-weighted MRI scans were obtained in 337 adults and voxel-based morphometric analyses were applied to detect regional gray matter volume differences related to hypertension, diabetes, smoking, and hyperlipidemia in men and women, respectively. Hypertension-related gray matter volume reduction was found in right superior, bilateral medial frontal, left superior temporal and left precentral gyri in men. No regional differences in gray matter related to hypertension were seen in women. Conversely, female but not male smokers had more gray matter volume in right fusiform gyrus and right temporal subgyral gray matter. No differences were observed in gray matter volume in association with diabetes or hyperlipidemia for men or women. Our results suggest that there are different patterns of regional effects in gray matter volume in relation to different cerebrovascular risk factors, and sex differences for the same risk factors.
研究了假定的脑血管危险因素对一个居住在社区、未患痴呆症的60至64岁队列人群灰质体积的影响。对337名成年人进行了头颅T1加权磁共振成像扫描，并应用基于体素的形态计量学分析，分别检测与高血压、糖尿病、吸烟和高脂血症相关的男性和女性区域灰质体积差异。在男性中，发现高血压相关的灰质体积减少出现在右侧额上回、双侧额中回、左侧颞上回和左侧中央前回。女性未发现与高血压相关的灰质区域差异。相反，女性吸烟者（而非男性吸烟者）右侧梭状回和右侧颞下回灰质体积更多。男性或女性与糖尿病或高脂血症相关的灰质体积未观察到差异。我们的结果表明，与不同脑血管危险因素相关的灰质体积区域效应模式不同，且相同危险因素存在性别差异。
