在非酒精依赖的日本男性中，全脑灰质体积和局部灰质体积均与终生酒精摄入量呈负相关：一项容积分析和基于体素的形态学测量。
Both global gray matter volume and regional gray matter volume negatively correlate with lifetime alcohol intake in non-alcohol-dependent Japanese men: a volumetric analysis and a voxel-based morphometry.
作者信息
Taki Yasuyuki, Kinomura Shigeo, Sato Kazunori, Goto Ryoi, Inoue Kentaro, Okada Ken, Ono Shuichi, Kawashima Ryuta, Fukuda Hiroshi
机构信息
Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
出版信息
Alcohol Clin Exp Res. 2006 Jun;30(6):1045-50. doi: 10.1111/j.1530-0277.2006.00118.x.
BACKGROUND
Non-alcohol-dependent heavy drinkers, as well as alcohol-dependent individuals, show brain atrophy. The purpose of this study was to evaluate whether there are correlations between global and regional gray matter volumes and the lifetime alcohol intake using volumetric analysis and voxel-based morphometry (VBM) among Japanese non-alcohol-dependent male individuals.
METHODS
High-resolution three-dimensional magnetic resonance images were acquired from 405 Japanese non-alcohol-dependent male individuals. The collected images were normalized, segmented for volumetric analysis, and additionally smoothed for VBM. For volumetric analysis, the partial correlation coefficient was estimated between the gray matter ratio, which represents the percentage of gray matter volume in the intracranial volume, and the lifetime alcohol intake adjusted for the age of each subject. Multiple regression analysis was performed among regional gray matter volume, lifetime alcohol intake, and age using VBM.
RESULTS
Volumetric analysis revealed that gray matter ratio showed a negative correlation with the lifetime alcohol intake adjusted for age (p=0.059, partial correlation coefficient=-0.091). The VBM revealed that the gray matter volumes of the bilateral middle frontal gyri showed a significant negative correlation with the lifetime alcohol intake adjusted for age and systolic blood pressure (left side, p=0.006, Z=4.77; right side, p=0.023, Z=4.45, and p=0.046, Z=4.27).
CONCLUSIONS
Our study suggests that non-alcohol-dependent Japanese male individuals show that both global gray matter volume and regional gray matter volume have negative correlations with the lifetime alcohol intake. Our study may contribute to clarifying the mechanism underlying the brain structural changes because of alcohol influence in healthy non-alcohol-dependent individuals.
背景
非酒精依赖的重度饮酒者以及酒精依赖者均表现出脑萎缩。本研究的目的是利用容积分析和基于体素的形态学测量（VBM）来评估日本非酒精依赖男性个体的全脑和局部灰质体积与终生酒精摄入量之间是否存在相关性。
方法
从405名日本非酒精依赖男性个体获取高分辨率三维磁共振图像。对收集到的图像进行归一化处理，分割以进行容积分析，并另外进行平滑处理以用于VBM。对于容积分析，估计灰质比例（代表颅内体积中灰质体积的百分比）与根据每个受试者年龄调整后的终生酒精摄入量之间的偏相关系数。使用VBM对局部灰质体积、终生酒精摄入量和年龄进行多元回归分析。
结果
容积分析显示，灰质比例与根据年龄调整后的终生酒精摄入量呈负相关（p = 0.059，偏相关系数 = -0.091）。VBM显示，双侧额中回的灰质体积与根据年龄和收缩压调整后的终生酒精摄入量呈显著负相关（左侧，p = 0.006，Z = 4.77；右侧，p = 0.023，Z = 4.45，以及p = 0.046，Z = 4.27）。
结论
我们的研究表明，非酒精依赖的日本男性个体中，全脑灰质体积和局部灰质体积均与终生酒精摄入量呈负相关。我们的研究可能有助于阐明健康的非酒精依赖个体因酒精影响而导致脑结构变化的潜在机制。
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