子宫肌瘤在孕期的体积变化：肌瘤真的会生长吗？

Volume change of uterine myomas during pregnancy: do myomas really grow?

作者信息

Hammoud Ahmad O, Asaad Radwan, Berman Jay, Treadwell Marjorie C, Blackwell Sean, Diamond Michael P

机构信息

Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah 84132, USA.

出版信息

J Minim Invasive Gynecol. 2006 Sep-Oct;13(5):386-90. doi: 10.1016/j.jmig.2006.04.003.

DOI:10.1016/j.jmig.2006.04.003

PMID:16962519

Abstract

STUDY OBJECTIVE

To estimate changes in uterine myoma volume during pregnancy.

DESIGN

Review of departmental electronic perinatal database and medical records. Canadian Task Force Classification II-3.

SETTING

Obstetrical ultrasound unit in an academic tertiary care center.

PATIENTS

One hundred-seven patients diagnosed with uterine myomas during pregnancy and who had two or more obstetrical ultrasounds in different periods of pregnancy.

INTERVENTIONS

We analyzed the change in volume of uterine myomas between the first half of pregnancy (up until 19 weeks), third quarter (20-30 weeks), and last quarter (31 weeks to term). The volume of largest uterine myoma was calculated using the formula Volume (mm3)=Pi/6x(length mm)x(width mm)x(height mm).

MEASUREMENTS AND MAIN RESULTS

The mean age of the population was 31+/-6 years. Between the first and the second study periods, the percentage of uterine myomas that decreased in size was 55.1% (95% CI: 43-66), with a mean decrease in volume of 35%+/-4%; while the percentage of uterine myomas that enlarged was 44.9% (95% CI: 34-56), with a mean increase in volume of 69%+/-11%. Between the second and the third study periods, 75% (95% CI: 56-87) became smaller, with a mean decrease in volume of 30%+/-3%; while 25% (95% CI: 13-43) enlarged, with a mean increase in volume of 102%+/-62%.

CONCLUSION

Contrary to common belief, we found that uterine myomas commonly decrease in volume over the course of pregnancy.

摘要

研究目的

评估孕期子宫肌瘤体积的变化。

设计

回顾部门电子围产期数据库和病历。加拿大工作组分类II-3。

地点

一所学术性三级医疗中心的产科超声科室。

患者

107例在孕期被诊断为子宫肌瘤且在孕期不同阶段接受过两次或更多次产科超声检查的患者。

干预措施

我们分析了妊娠前半期（直至19周）、妊娠第三季度（20 - 30周）和最后一季度（31周直至足月）子宫肌瘤体积的变化。最大子宫肌瘤的体积通过公式体积（mm³）=π/6×（长度mm）×（宽度mm）×（高度mm）计算得出。

测量指标及主要结果

研究人群的平均年龄为31±6岁。在第一个和第二个研究阶段之间，子宫肌瘤体积减小的比例为55.1%（95%置信区间：43 - 66），体积平均减小35%±4%；而子宫肌瘤体积增大的比例为44.9%（95%置信区间：34 - 56），体积平均增大69%±11%。在第二个和第三个研究阶段之间，75%（95%置信区间：56 - 87）的肌瘤变小，体积平均减小30%±3%；而25%（95%置信区间：13 - 43）的肌瘤增大，体积平均增大102%±62%。