Department of Gynecological, Obstetrical Sciences and Reproductive Medicine, University Hospital, Messina, Italy.
Ultrasound Obstet Gynecol. 2011 Mar;37(3):361-5. doi: 10.1002/uog.8826. Epub 2011 Feb 10.
To evaluate volumetric changes of uterine myomas (fibroids) during pregnancy.
This was an observational, longitudinal and prospective study of 38 consecutive Caucasian women with singleton pregnancies and a total of 42 uterine myomas, enrolled from a cohort of 1492 women who took part in our first-trimester Down syndrome screening program. Myoma volume was evaluated by ultrasound at 11-14, 20-22 and 32-34 weeks of gestation.
Mean myoma volume increased significantly throughout pregnancy. Taking a volumetric change of > 10% between gestational periods to be an increase in size, 71.4% of uterine myomas increased in size between the first and second gestational periods, while this percentage was slightly lower (66.6%) between the second and third periods. Logistic regression analysis revealed that greater maternal age was correlated with a reduction/no change in overall myoma size and multiparity was correlated with a decrease/no change between the first and second trimesters, while a higher prepregnancy maternal body mass index (BMI) was correlated with a volumetric increase between the first and second trimesters and a decrease/no change between the second and third trimesters.
Fibroids enlarge during pregnancy regardless of their initial size or local factors, and maternal age, prepregnancy BMI and parity are apparently correlated with these changes.
评估妊娠期间子宫肌瘤（纤维瘤）的体积变化。
这是一项对 38 例连续的高加索白人单胎妊娠妇女和总共 42 个子宫肌瘤进行的观察性、纵向和前瞻性研究，这些妇女均来自于我们的唐氏综合征筛查计划的 1492 名女性队列。在妊娠 11-14 周、20-22 周和 32-34 周时通过超声评估肌瘤体积。
子宫肌瘤体积在整个妊娠期间显著增加。将妊娠期间体积变化>10%视为大小增加，71.4%的子宫肌瘤在第一和第二妊娠期间增大，而这一比例在第二和第三妊娠期间略低（66.6%）。逻辑回归分析显示，母亲年龄较大与整体肌瘤大小的减少/不变相关，多胎与第一和第二孕期之间的减少/不变相关，而较高的孕前母体体重指数（BMI）与第一和第二孕期之间的体积增加以及第二和第三孕期之间的减少/不变相关。
子宫肌瘤在妊娠期间会增大，无论其初始大小或局部因素如何，母亲年龄、孕前 BMI 和产次与这些变化明显相关。
